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Analysis of novel members of FAHFA lipid class derived from omega 3-PUFA by LC-MS/MS and LC-MS/MS/MS
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SYSNO ASEP 0472359 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Analysis of novel members of FAHFA lipid class derived from omega 3-PUFA by LC-MS/MS and LC-MS/MS/MS Author(s) Rombaldová, Martina (FGU-C) RID, ORCID
Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Březinová, Marie (FGU-C) ORCID
Slavíková, Barbora (UOCHB-X) RID, ORCID
Pošta, Martin (UOCHB-X) RID
Beier, Petr (UOCHB-X) RID, ORCID
Janovská, Petra (FGU-C) RID, ORCID
Veleba, J. (CZ)
Kopecký Jr., J. (CZ)
Kudová, Eva (UOCHB-X) RID, ORCID
Pelikánová, T. (CZ)
Kopecký, Jan (FGU-C) RID, ORCIDSource Title Proceedings of the 12th International Students Conference. - Prague : Charles University in Prague, Faculty of Science,, 2016 / Nesměrák K. - ISBN 978-80-7444-044-1 Pages s. 103-107 Number of pages 5 s. Publication form Print - P Action International Students Conference "Modern Analytical Chemistry" /12./ Event date 22.09.2016 - 23.09.2016 VEvent location Prague Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords branched fatty acid ; lipidomics ; mass spectrometry ; omega 3-PUFA Subject RIV CC - Organic Chemistry Subject RIV - cooperation Institute of Physiology - Endocrinology, Diabetology, Metabolism, Nutrition R&D Projects LH14040 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GB14-36804G GA ČR - Czech Science Foundation (CSF) Institutional support UOCHB-X - RVO:61388963 ; FGU-C - RVO:67985823 UT WOS 000391253800019 Annotation White adipose tissue (WAT) is a complex organ with both metabolic and endocrine functions. Dysregulation of all of these functions of WAT, together with low-grade inflammation of the tissue in obesity, contributes to the development of insulin resistance and type 2 diabetes. Omega-3 polyunsaturated fatty acids (PUFA) of marine origin play an important role in resolution of inflammation and exert beneficial metabolic effects. Using LC-MS/MS method, we elucidated the structures of novel members of fatty acid esters of hydroxy fatty acids (FAHFA), which were present in murine and human serum and WAT after omega-3 PUFA supplementation in diet. These compounds contained DHA esterified to 9- and 13-hydroxyoctadecadienoic acid (HLA) termed 9-DHAHLA and 13-DHAHLA, and were synthesized in WAT. Our results document the existence of novel lipid mediators, which are involved in the beneficial anti-inflammatory effects attributed toomega-3 PUFA, in both miceandhumans. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2017
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