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The Biology and Therapeutic Applications of Mesenchymal Cells
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SYSNO ASEP 0472194 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title The role of mesenchymal stromal cells in spinal cord injury Author(s) Jendelová, Pavla (UEM-P) RID, ORCID
Machová-Urdzíková, Lucia (UEM-P) ORCID
Syková, Eva (UEM-P) RIDSource Title The Biology and Therapeutic Applications of Mesenchymal Cells. - Oxford : Wiley-Blackwell, 2017 / Atkinson Kerry - ISBN 978-1-118-90751-1 Pages s. 714-729 Number of pages 16 s. Number of pages 1048 Publication form Print - P Language eng - English Country CZ - Czech Republic Keywords mesenchymal stromal cells ; bone marrow ; adipose tissue ; umbilical cord ; spinal cord injury ; clinical trials ; therapeutic use ; paracrine effect Subject RIV FP - Other Medical Disciplines OECD category Neurosciences (including psychophysiology R&D Projects LO1309 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEM-P - RVO:68378041 Annotation Spinal cord injury (SCI) is one of the most devastating diseases that affects patients and their families for the rest of their lives. Among many treatments being developed for SCI, the placement of different types of grafts embedded with cell populations into areas of damage has been one of the most commonly used
regenerative approaches ,attracting scientists and physicians for the last 15 years. Stem/stromal cells are able to secrete a large repertoire of signaling molecules, including anti-inflammatory cytokines and growth factors, which may modulate the inhibitory environment of SCI while increasing trophic support to the resident cells. The chapter describes the pathology of spinal cord injury, the use of mesenchymal stromal cells derived from different sources in the treatment of SCI and their potential modifications and manipulations to reinforce their paracrine effect on neural tissue regeneration.
Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2018
Number of the records: 1