All-diamond functional surface micro-electrode arrays for brain-slice neural analysis

0465775 - ÚFCH JH 2018 RIV DE eng J - Journal Article
Vahidpour, F. - Curley, L. - Biró, I. - McDonald, M. - Croux, D. - Pobedinskas, P. - Haenen, K. - Giugliano, M. - Vlčková Živcová, Zuzana - Kavan, Ladislav - Nesládek, M.
All-diamond functional surface micro-electrode arrays for brain-slice neural analysis.
Physica Status Solidi A. Roč. 214, č. 2 (2017), č. článku 1532347. ISSN 1862-6300. E-ISSN 1862-6319
R&D Projects: GA ČR GA13-31783S
Institutional support: RVO:61388955
Keywords : impedance spectroscopy * microelectrode arrays * surface termination
OECD category: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Impact factor: 1.795, year: 2017

Diamond-based microelectrode arrays were fabricated by using nanocrystalline diamond as an insulating layer and conductive boron-doped in order to used them for analysis of brain cortical slices. MEA surface is solely composed of diamond, exposed to the cells. The impedance measurements showed negligible cross-talk between neighbouring diamond microelectrodes. Local field potentials related to neural signals were then successfully recorded from pharmacologically disinhibited rat cortical tissue slices, mechanically coupled on the surface of the MEA. The background signal level of the diamond MEAs was found to be lower than commercial Pt-based MEAs, under identical measurement conditions.
Permanent Link: http://hdl.handle.net/11104/0264231