Number of the records: 1
Trends and challenges in chemistry of acyclic nucleoside phosphonates
- 1.
SYSNO ASEP 0455024 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Trends and challenges in chemistry of acyclic nucleoside phosphonates Author(s) Krečmerová, Marcela (UOCHB-X) RID, ORCID Number of authors 1 Source Title 6th International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC'15) and 13th Annual Meeting of the Medicinal Chemistry Section of the Israel Chemical Society. - Rehovot : European Federation for Medicinal Chemistry, 2015
S. 164Number of pages 1 s. Publication form Print - P Action International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC'15) /6./ and Annual Meeting of the Medicinal Chemistry Section of the Israel Chemical Society /13./ Event date 15.11.2015-18.11.2015 VEvent location Rehovot Country IL - Israel Event type WRD Language eng - English Country IL - Israel Keywords 5-azacytosine ; PME-azaC ; acyclic nucleoside phosphonate ; antivirals ; prodrug Subject RIV CC - Organic Chemistry R&D Projects FR-TI4/625 GA MPO - Ministry of Industry and Trade (MPO) Institutional support UOCHB-X - RVO:61388963 Annotation Synthesis of prodrugs in a series of 5-azacytosine acyclic nucleoside phosphonates was described including their antiviral activity data. Interestingly, the antiviral activity was found in prodrugs of 1-[2-(phosphonomethoxy)ethyl]-5-azacytosine (PME-azaC) despite the fact that the parent free phosphonic acid is antivirally inactive. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2016
Number of the records: 1