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Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism
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SYSNO ASEP 0431311 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism Author(s) Pepino, M. Y. (US)
Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Samovski, D. (US)
Abumrad, N. A. (US)Source Title Annual Review of Nutrition - ISSN 0199-9885
Roč. 34, JULY (2014), s. 281-303Number of pages 22 s. Language eng - English Country US - United States Keywords fat taste ; chylomicron ; VLDL ; CCK ; secretin ; calcium ; FA binding ; phospholipase ; eicosanoid Subject RIV EB - Genetics ; Molecular Biology R&D Projects GP13-04449P GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000348455800012 EID SCOPUS 84904631280 DOI 10.1146/annurev-nutr-071812-161220 Annotation CD36 is a scavenger receptor that functions in high-affinity tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding site and a potential mechanism for FA transfer. It also presents the view that CD36 and FA signaling coordinate fat utilization, a view that is based on newly identified CD36 actions that involve oral fat perception, intestinal fat absorption, secretion of the peptides cholecystokinin and secretin, regulation of hepatic lipoprotein output, activation of beta oxidation by muscle, and regulation of the production of the FA-derived bioactive eicosanoids Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2015
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