Ovulation stimulation protocols utilizing GnRH-antagonist/hCG, promote cytotoxic cell populations, predominant in patients with embryo implantation complications

0421425 - MBÚ 2014 RIV SE eng J - Journal Article
Svoboda, Jan - Růžičková, Žaneta - Cuchalová, Lucie - Králíčková, M. - Řezáčová, J. - Vraná, M. - Fišerová, Anna - Richter, Jan - Madar, J.
Ovulation stimulation protocols utilizing GnRH-antagonist/hCG, promote cytotoxic cell populations, predominant in patients with embryo implantation complications.
Neuroendocrinology Letters. Roč. 34, č. 3 (2013), s. 249-257. ISSN 0172-780X. E-ISSN 2354-4716
R&D Projects: GA MZd NR9135
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : Gonadotropin-releasing hormone * embryo implantation * gonadotropin hormone
Subject RIV: EC - Immunology; CE - Biochemistry (UMCH-V)
Impact factor: 0.935, year: 2013
http://www.nel.edu/archive_issues/o/34_3/NEL340313A03_Svoboda--Fiserova.pdf

Gonadotropin-releasing hormone (GnRH) antagonist combined with the human chorionic gonadotropin hormone (hCG) is commonly used in assisted reproduction techniques (ARTs) to induce controlled ovarian hyperstimulation (COH) and to synchronize oocyte maturation. While hCG is known to have immunomodulatory properties, we aimed to assess its effect on immunological changes, with respect to HLA-G binding receptors and embryo implantation success. The study involved 103 subjects, including patients undergoing COH protocols (n=66), divided on the basis of the pair's fertility disorder (FD) causes (female FD, n=29; male FD, n=37), and age matched healthy women (n=37). The relative distribution of T cell (CD3+/CD4+, CD3+/CD8+) and NK cell (CD56bright/CD16-, CD56dim/CD16+) populations was evaluated together with HLA-G ligands KIR2DL4 and LILRB1 expression by flow cytometry in the peripheral blood of all subjects, as well as in patient follicular fluids
Permanent Link: http://hdl.handle.net/11104/0227763