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Biological Evaluation of Polydimethylsiloxane Modified by Calcium Phosphate Nanoparticles for Potential Application in Spine Surgery
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SYSNO ASEP 0398795 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biological Evaluation of Polydimethylsiloxane Modified by Calcium Phosphate Nanoparticles for Potential Application in Spine Surgery Author(s) Suchý, Tomáš (USMH-B) RID, ORCID, SAI
Rýglová, Šárka (USMH-B) RID, ORCID, SAI
Balík, Karel (USMH-B) RID, ORCID
Smetana, K. (CZ)
Šupová, Monika (USMH-B) RID, ORCID, SAI
Sucharda, Zbyněk (USMH-B)
Filová, Elena (FGU-C) RID, ORCID
Havlíková, Jana (FGU-C)
Bačáková, Lucie (FGU-C) RID, ORCID
Martynková, G.S. (CZ)Source Title Science of Advanced Materials - ISSN 1947-2935
Roč. 5, č. 5 (2013), s. 484-493Number of pages 10 s. Publication form Print - P Language eng - English Country US - United States Keywords Composite Materials ; Biomaterials ; Polymers ; Ceramics Subject RIV JI - Composite Materials Subject RIV - cooperation Institute of Physiology - Biotechnology ; Bionics R&D Projects GA106/09/1000 GA ČR - Czech Science Foundation (CSF) FT-TA3/131 GA MPO - Ministry of Industry and Trade (MPO) Institutional support USMH-B - RVO:67985891 ; FGU-C - RVO:67985823 UT WOS 000322604700008 EID SCOPUS 84880954047 DOI 10.1166/sam.2013.1478 Annotation The biological properties of a composite made of polydimethylsiloxane matrix and two kinds of calcium phosphate nanoparticles (hydroxyapatite, beta tricalcium phosphate) were tested by means of in vitro and in vivo investigations. Chemical and phase analyses of the nanoparticles were performed. The effects of different volume fractions of nanoparticles were investigated. Human osteoblast-like cell cultures (MG 63) demonstrated that the addition of 5–15 vol.% of nanoparticles had a significantly positive effect on osteoblast viability, and that high concentration did not support cell proliferation. The highest rates of osteointegration in pig bone were attained for implants modified by 15 vol.% hydroxyapatite and more intensive formation of new bone tissue was observed. Our study indicates that hydroxyapatite probably better imitates the composition and structure of the mineral phase of real bone. Workplace Institute of Rock Structure and Mechanics Contact Iva Švihálková, svihalkova@irsm.cas.cz, Tel.: 266 009 216 Year of Publishing 2014
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