Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester

0385103 - ÚMCH 2013 RIV NL eng J - Journal Article
Jäger, Eliezer - Jäger, Alessandro - Chytil, Petr - Etrych, Tomáš - Říhová, Blanka - Giacomelli, F. C. - Štěpánek, Petr - Ulbrich, Karel
Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester.
Journal of Controlled Release. Roč. 165, č. 2 (2013), s. 153-161. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA AV ČR IAAX00500803; GA ČR GA202/09/2078; GA ČR GPP207/11/P551
Institutional research plan: CEZ:AV0Z40500505; CEZ:AV0Z50200510
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : combination therapy * polymeric core-shell nanoparticles * docetaxel
Subject RIV: CD - Macromolecular Chemistry; EC - Immunology (MBU-M)
Impact factor: 7.261, year: 2013

The preparation of core-shell polymeric nanoparticles simultaneously loaded with docetaxel (DTXL) and doxorubicin (DOX) is reported herein. The self-assembly of the aliphatic biodegradable copolyester PBS/PBDL (poly(butylene succinate-co-butylene dilinoleate)) and HPMA-based copolymers (N-(2-hydroxypropyl)methacrylamide-based copolymers) hydrophobically modified by the incorporation of cholesterol led to the formation of narrow-size-distributed (PDI<0.10) sub-200-nm polymeric nanoparticles suitable for passive tumor-targeting drug delivery based on the size-dependent EPR (enhanced permeability and retention) effect. The PHPMA provided to the self-assembled nanoparticle stability against aggregation as evaluated in vitro. Additionally, the obtained self-assembled nanoparticles enable further development of targeting strategies based on the use of multiple ligands attached to an HPMA copolymer on the particle surface for simultaneous passive and active targeting and different combination therapies.
Permanent Link: http://hdl.handle.net/11104/0217256