Non-fouling hydrogels of 2-hydroxyethyl methacrylate and zwitterionic carboxybetaine (meth)acrylamides

0384769 - ÚMCH 2013 RIV US eng J - Journal Article
Kostina, Nina Yu. - Rodriguez-Emmenegger, Cesar - Houska, Milan - Brynda, Eduard - Michálek, Jiří
Non-fouling hydrogels of 2-hydroxyethyl methacrylate and zwitterionic carboxybetaine (meth)acrylamides.
Biomacromolecules. Roč. 13, č. 12 (2012), s. 4164-4170. ISSN 1525-7797. E-ISSN 1526-4602
R&D Projects: GA AV ČR KAN200520804; GA ČR GAP205/12/1702; GA ČR GAP106/12/1451
Institutional research plan: CEZ:AV0Z40500505
Institutional support: RVO:61389013
Keywords : zwitterionic hydrogels * non-fouling properties * carboxybetaine
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 5.371, year: 2012

Five poly(betaine) brushes were prepared, and their resistance to blood plasma fouling was studied. Two carboxybetaines monomers were copolymerized with 2-hydroxyethyl methacrylate (HEMA) to prepare novel hydrogels. By increasing the content of the zwitterionic comonomer, a 4-fold increase in the water content could be achieved while retaining mechanical properties close to the widely used poly(HEMA) hydrogels. All hydrogels showed an unprecedentedly low fouling from blood plasma. Remarkably, by copolymerization with 10 mol % of carboxybetaine acrylamide, hydrogels fully resistant to blood plasma were prepared.
Permanent Link: http://hdl.handle.net/11104/0216114