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Production of proteolytic enzymes in mast cells, fibroblasts, vascular smooth muscle and endothelial cells cultivated under normoxic or hypoxic conditions
- 1.0355375 - FGÚ 2011 RIV CZ eng J - Journal Article
Maxová, H. - Bačáková, Lucie - Lisá, Věra - Novotná, J. - Tomášová, H. - Vízek, M. - Herget, J.
Production of proteolytic enzymes in mast cells, fibroblasts, vascular smooth muscle and endothelial cells cultivated under normoxic or hypoxic conditions.
Physiological Research. Roč. 59, č. 5 (2010), s. 711-719. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR(CZ) GA305/08/0108; GA MŠMT(CZ) 1M0510
Institutional research plan: CEZ:AV0Z50110509
Keywords : hypoxia * metalloproteinases * tryptase * chymase * immunofluorescence
Subject RIV: EI - Biotechnology ; Bionics
Impact factor: 1.646, year: 2010
We tested in vitro production of MMPs and serine proteases in four cell types cultivated for 48 h under normoxic or hypoxic conditions. Among all cell types, mast cells are the most abundant source of proteolytic enzymes under normoxic and hypoxic conditions. Morover, in these cells hypoxia increases the production of both specific serine proteases trypase and chymase, which can act as MMPs activators
Permanent Link: http://hdl.handle.net/11104/0194159
Number of the records: 1