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Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat
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SYSNO ASEP 0340207 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Co-transplantation of olfactory ensheathing glia and mesenchymal stromal cells does not have synergistic effects after spinal cord injury in the rat Author(s) Amemori, Takashi (UEM-P) RID
Jendelová, Pavla (UEM-P) RID, ORCID
Růžičková, Kateřina (UEM-P)
Arboleda Toro, David (UEM-P)
Syková, Eva (UEM-P) RIDSource Title Cytotherapy. - : Elsevier - ISSN 1465-3249
Roč. 12, č. 2 (2010), s. 212-225Number of pages 14 s. Language eng - English Country NO - Norway Keywords mesemchymal stromal cells ; olfactory ensheathing glia ; spinal cord injury Subject RIV FH - Neurology R&D Projects IAA500390902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA309/06/1246 GA ČR - Czech Science Foundation (CSF) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000275110600010 DOI 10.3109/14653240903440103 Annotation Olfactory ensheathing glia (OEG) and mesenchymal stromal cells (MSC) have been investigated as promising candidates for spinal cord repair. In this study, the effect of the transplantation of OEG and/or MSC on behavioral, electrophysiologic and histologic outcomes after SCI was studied. Both OEG and MSC could foster locomotor function by sparing the spinal cord, but their combined advantages provide no added benefit to SCI therapy. We speculate that to maximize the advantageous effects of co-transplantation, direct implantation of OEG into the spinal cord lesion accompanied by intravenous injection of MSC might be more efficacious approach to the co-transplantation of OEG and MSC. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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