Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs

0212194 - UT-L 20020140 RIV CZ eng C - Conference Paper (international conference)
Matějovič, P. - Bahníková, M. - Pásek, Michal - Šimurdová, M. - Šimurda, J.
Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs.
Analysis of biomedical signals and images. Brno: University of Technology VUTIUM Press, 2002 - (Jan, J.; Kozumplík, J.; Provazník, I.), s. 214-216. ISBN 80-214-2633-0. ISSN 1211-412X.
[Biosignal 2002. Brno (CZ), 26.06.2002-28.06.2002]
Institutional research plan: CEZ:AV0Z2076919
Keywords : cardiac cell * sodium current * antiarrhythmic drugs
Subject RIV: BO - Biophysics

Ionic currents recorded in voltage clamp experiments on enzymatically isolated rat ventricular myocytes were analyzed with the aim to study the voltage and frequency dependence of sodium current block induced by two antiarrhythmic drugs: ajmaline and propafenone. The levels of block produced by both examined agents were clearly related to membrane voltage. Interestingly, ajmaline, in contrast to propafenone, did not show frequency and use dependent effect. These differences are analyzed.
Permanent Link: http://hdl.handle.net/11104/0107742