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Cardiac cachexia is associated with altered expression of genes related to iron and lipid metabolism
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SYSNO ASEP 0583471 Document Type A - Abstract R&D Document Type O - Ostatní Title Cardiac cachexia is associated with altered expression of genes related to iron and lipid metabolism Author(s) Janovská, Petra (FGU-C) RID, ORCID
Kobets, Tetyana (FGU-C)
Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Steiner Mrázová, Lenka (FGU-C)
Stránecký, V. (CZ)
Melenovský, V. (CZ)
Kopecký, Jan (FGU-C) RID, ORCIDArticle number 57ASM-139 Source Title European Journal of Clinical Investigation. - : Wiley - ISSN 0014-2972
Roč. 53, Suppl.1 (2023)Number of pages 1 s. Action ANNUAL SCIENTIFIC MEETING /57./ Event date 07.06.2023 - 09.06.2023 VEvent location Praha Country CZ - Czech Republic Event type WRD Language eng - English Country US - United States Keywords heart failure ; adipose tissue ; cardiac cachexia OECD category Cardiac and Cardiovascular systems R&D Projects LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 001043106300074 DOI 10.1111/eci.13992 Annotation Deeper lipidomic analysis in EAT uncovered potential higher oxidation of polyunsaturated lipids in cachexia. Analysis of significantly regulated phosphatidyl ethanolmanines revealed higher content of arachidonic acid at sn2 position. Changes in iron and lipid metabolism in both EAT and MYO can be key markers of cardiac cachexia, they are more pronounced in EAT, and suggest the role of EAT-MYO microenvironment in the development of HF. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2024 Electronic address https://onlinelibrary.wiley.com/doi/10.1111/eci.13992
Number of the records: 1