Transcriptomic alterations in the olfactory bulb induced by exposure to air pollution: Identification of potential biomarkers and insights into olfactory system function

0582006 - ÚEM 2024 RIV NL eng J - Journal Article
Saveleva, L. - Šíma, Michal - Kléma, J. - Krejčík, Zdeněk - Vartiainen, N. - Sitnikova, V. - Belaya, I. - Malm, T. - Jalava, P.I. - Rössner st., Pavel - Kanninen, K. M.
Transcriptomic alterations in the olfactory bulb induced by exposure to air pollution: Identification of potential biomarkers and insights into olfactory system function.
Environmental Toxicology and Pharmacology. Roč. 104, nov. (2023), č. článku 104316. ISSN 1382-6689. E-ISSN 1872-7077
R&D Projects: GA MŠMT(CZ) LM2018124; GA MŠMT(CZ) LM2018133; GA MŠMT(CZ) EF16_013/0001821
Institutional support: RVO:68378041
Keywords : air pollution * ultrafine particles (UFP) * brain * olfactory bulb * odorant-binding protein (OBP) * myelin protein zero (Mpz)
OECD category: Public and environmental health
Impact factor: 4.3, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S1382668923002582?via%3Dihub

This study evaluated how exposure to the ubiquitous air pollution component, ultrafine particles (UFPs), alters the olfactory bulb (OB) transcriptome. The study utilised a whole-body inhalation chamber to simulate real-life conditions and focused on UFPs due to their high translocation and deposition ability in OBs as well as their prevalence in ambient air. Female C57BL/6J mice were exposed to clean air or to freshly generated combustion derived UFPs for two weeks, after which OBs were dissected and mRNA transcripts were investigated using RNA sequencing analysis. For the first time, transcriptomics was applied to determine changes in mRNA expression levels occurring after subacute exposure to UFPs in the OBs. We found forty-five newly described mRNAs to be involved in air pollution-induced responses, including genes involved in odorant binding, synaptic regulation, and myelination signalling pathway, providing new gene candidates for future research. This study provides new insights for the environmental science and neuroscience fields and nominates future research directions.
Permanent Link: https://hdl.handle.net/11104/0350728