Number of the records: 1
The activation of dormant ependymal cells following spinal cord injury
- 1.
SYSNO ASEP 0581951 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The activation of dormant ependymal cells following spinal cord injury Author(s) Rodriguez-Jiménez, F.J. (ES)
Jendelová, Pavla (UEM-P) RID, ORCID
Erceg, Slaven (UEM-P) RID, ORCIDArticle number 175 Source Title Stem Cell Research & Therapy. - : BioMed Central
Roč. 14, č. 1 (2023)Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords spinal cord injury ; ependymal cells ; activation ; regeneration OECD category Neurosciences (including psychophysiology R&D Projects EF15_003/0000419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 001019958100002 EID SCOPUS 85163986349 DOI 10.1186/s13287-023-03395-4 Annotation Ependymal cells, a dormant population of ciliated progenitors found within the central canal of the spinal cord, undergo significant alterations after spinal cord injury (SCI). Understanding the molecular events that induce ependymal cell activation after SCI represents the first step toward controlling the response of the endogenous regenerative machinery in damaged tissues. This response involves the activation of specific signaling pathways in the spinal cord that promotes self-renewal, proliferation, and differentiation. We review our current understanding of the signaling pathways and molecular events that mediate the SCI-induced activation of ependymal cells by focusing on the roles of some cell adhesion molecules, cellular membrane receptors, ion channels (and their crosstalk), and transcription factors. An orchestrated response regulating the expression of receptors and ion channels fine-tunes and coordinates the activation of ependymal cells after SCI or cell transplantation. Understanding the major players in the activation of ependymal cells may help us to understand whether these cells represent a critical source of cells contributing to cellular replacement and tissue regeneration after SCI. A more complete understanding of the role and function of individual signaling pathways in endogenous spinal cord progenitors may foster the development of novel targeted therapies to induce the regeneration of the injured spinal cord Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2024 Electronic address https://stemcellres.biomedcentral.com/articles/10.1186/s13287-023-03395-4
Number of the records: 1