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Synthesis and Application of Novel Fluorescent Labeling Tags for Oligosaccharide and N-Linked Glycan Analysis
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SYSNO ASEP 0580627 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Synthesis and Application of Novel Fluorescent Labeling Tags for Oligosaccharide and N-Linked Glycan Analysis Author(s) Veselý, H. (CZ)
Greguš, M. (CZ)
Pížová, H. (CZ)
Smolková, Denisa (UIACH-O)
Čmelík, Richard (UIACH-O) RID
Lavická, Jana (UIACH-O) ORCID, RID
Bobáľ, P. (CZ)Number of authors 7 Source Title Book of Abstracts. - Prague : Czech Chemical Society, 2023
S. 1-1Number of pages 1 s. Publication form Online - E Action Advances in Organic, Bioorganic and Pharmaceutical Chemistry /57./ Event date 09.11.2023 - 11.11.2023 VEvent location Špindlerův Mlýn Country CZ - Czech Republic Event type EUR Language eng - English Country CZ - Czech Republic Keywords oligosaccharide ; novel fluorescent labeling tags Subject RIV CB - Analytical Chemistry, Separation OECD category Analytical chemistry R&D Projects GA22-00236S GA ČR - Czech Science Foundation (CSF) Institutional support UIACH-O - RVO:68081715 Annotation Monitoring glycosylation and investigating the influence of glycan structures on their function is an essential area of research, particularly in the diagnosis of disease and the study of mechanisms of pathogenesis. Analysis of glycans is still arduous because of their extreme structure complexity and conjugation diversity. But there are also instrumental aspects, such as the sensitivity limits of analyses. Therefore, glycan analysis is very often combined with fluorescence detection in addition to MS. In this work, we present the synthesis of novel fluorescent labeling tags for oligosaccharide and N-linked glycan analysis based on the hydrazide derivative of dipyrrometheneboron difluoride (BODIPY) and derivatives of 1,3-diaza-tricyclo[7.3.0.0³,⁷]dodeca-5,7,9,11-tetraene-2,4-dione. Workplace Institute of Analytical Chemistry Contact Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Year of Publishing 2024 Electronic address https://mab.uochb.cas.cz/liblice2023/programme.php
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