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Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes
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SYSNO ASEP 0580591 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes Author(s) Padilla-Mejia, N.E. (GB)
Field, Mark Christian (BC-A) ORCIDNumber of authors 2 Source Title FEBS Letters. - : Wiley - ISSN 0014-5793
Roč. 597, č. 20 (2023), s. 2501-2518Number of pages 18 s. Publication form Print - P Language eng - English Country US - United States Keywords pore complex components ; molecular architecture ; integrative structure ; a-type ; nucleoporin ; protein ; lamina ; chromatin ; form ; identification ; evolutionary diversity ; nuclear lamina ; nuclear pore complex ; nucleus ; trypanosoma Subject RIV EA - Cell Biology OECD category Cell biology Method of publishing Open access Institutional support BC-A - RVO:60077344 UT WOS 001085520900001 EID SCOPUS 85174145967 DOI 10.1002/1873-3468.14747 Annotation One of the remarkable features of eukaryotes is the nucleus, delimited by the nuclear envelope (NE), a complex structure and home to the nuclear lamina and nuclear pore complex (NPC). For decades, these structures were believed to be mainly architectural elements and, in the case of the NPC, simply facilitating nucleocytoplasmic trafficking. More recently, the critical roles of the lamina, NPC and other NE constituents in genome organisation, maintaining chromosomal domains and regulating gene expression have been recognised. Importantly, mutations in genes encoding lamina and NPC components lead to pathogenesis in humans, while pathogenic protozoa disrupt the progression of normal development and expression of pathogenesis-related genes. Here, we review features of the lamina and NPC across eukaryotes and discuss how these elements are structured in trypanosomes, protozoa of high medical and veterinary importance, highlighting lineage-specific and conserved aspects of nuclear organisation. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2024 Electronic address https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14747
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