Investigation of anti-neuronal antibodies and disparity in central hypersomnias.

0579545 - MBÚ 2024 RIV NL eng J - Journal Article
Procházková, Petra - Šonka, K. - Roubalová, Radka - Ježková, Janet - Nevšímalová, S. - Bušková, J. - Merková, R. - Dvořáková, T. - Příhodová, I. - Dostálová, S. - Tlaskalová-Hogenová, Helena
Investigation of anti-neuronal antibodies and disparity in central hypersomnias.
Sleep Medicine. Roč. 113, January 24 (2024), s. 220-231. ISSN 1389-9457. E-ISSN 1878-5506
R&D Projects: GA MZd(CZ) NU20-04-00088
Institutional support: RVO:61388971
Keywords : Narcolepsy * Sleepiness * Autoantibodies * Hypersomnia * Neuropeptides * Immunity
OECD category: Microbiology
Impact factor: 4.8, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1389945723004653?via%3Dihub

STUDY OBJECTIVES: Microbial antigens can elicit an immune response leading to the production of autoantibodies cross-reacting with autoantigens. Still, their clinical significance in human sera in the context of brain diseases is unclear. Therefore, assessment of natural autoantibodies reacting with their neuropeptides may elucidate the autoimmune etiology of central hypersomnias. The study aims to determine whether serum autoantibody levels differ in patients with different types of central hypersomnias (narcolepsy type 1 and 2, NT1 and NT2, idiopathic hypersomnia, IH) and healthy controls and if the differences could suggest the participation of autoantibodies in disease pathogenesis.
Permanent Link: https://hdl.handle.net/11104/0348430