Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy

Kirakci, Kaplan; Pola, Robert; Tavares, Marina Rodrigues; Pechar, Michal; Přibyl, T.; Křížová, I.; Zelenka, J.; Ruml, T.; Etrych, Tomáš; Lang, Kamil

doi:https://dx.doi.org/10.1039/d3ma00577a

Number of the records: 1

Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy

1.

SYSNO ASEP	0578624
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy
Author(s)	Kirakci, Kaplan (UACH-T)_{SAI, RID, ORCID} Pola, Robert (UMCH-V)_{RID, ORCID} Tavares, Marina Rodrigues (UMCH-V)_{ORCID, RID} Pechar, Michal (UMCH-V)_{RID, ORCID} Přibyl, T. (CZ) Křížová, I. (CZ) Zelenka, J. (CZ) Ruml, T. (CZ) Etrych, Tomáš (UMCH-V)_{RID, ORCID} Lang, Kamil (UACH-T)_{SAI, RID, ORCID}
Number of authors	10
Source Title	Materials Advances. - : Royal Society of Chemistry Roč. 4, č. 23 (2023), s. 6389-6395
Number of pages	7 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	gold nanoparticles ; photodynamic therapy ; radiation ; luminescence
Subject RIV	CA - Inorganic Chemistry
OECD category	Inorganic and nuclear chemistry
R&D Projects	GA21-11688S GA ČR - Czech Science Foundation (CSF)
	LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	UACH-T - RVO:61388980 ; UMCH-V - RVO:61389013
UT WOS	001105096300001
EID SCOPUS	85176776822
DOI	10.1039/d3ma00577a
Annotation	Radiodynamic therapy treats deep-seated tumors by exploiting radiosensitizers (RSs) that are delivered to tumors and produce reactive oxygen species upon X-ray irradiation. Octahedral molybdenum clusters (Mo6) have shown promise as RSs, but their direct administration is hampered by their limited stability and low solubility in the biological medium. Association of the Mo6 clusters with organic polymers can overcome this issue and improve their bioavailability. Herein, we have conjugated a dibenzocyclooctyne-functionalized N-(2-hydroxypropyl)methacrylamide copolymer with a Mo6 cluster bearing azido ligands via a copper-free click reaction. The resulting nanosized Mo6 cluster/polymer conjugate exhibited long-term stability of its colloidal and luminescence properties in phosphate-buffered saline, and displayed photosensitized formation of singlet oxygen, affirming its potential for photodynamic processes. The conjugate was not toxic towards HeLa cells, demonstrated phototoxic effects upon blue-light irradiation, with an better therapeutic window than the bare Mo6 cluster, and showed promise as an RS, enhancing cell growth suppression upon X-ray irradiation. Overall, this nanosystem constitutes a propitious theranostic tool for photo/radiodynamic applications.
Workplace	Institute of Inorganic Chemistry
Contact	Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931
Year of Publishing	2024
Electronic address	https://hdl.handle.net/11104/0347782

Number of the records: 1