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Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms
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SYSNO ASEP 0575136 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms Author(s) Kuneš, Jaroslav (UOCHB-X) ORCID, RID
Hojná, S. (CZ)
Mráziková, Lucia (UOCHB-X)
Montezano, A. (CA)
Touyz, R. M. (CA)
Maletínská, Lenka (UOCHB-X) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 72, Suppl. 2 (2023), S73-S90Number of pages 18 s. Language eng - English Country CZ - Czech Republic Keywords obesity ; cardiovascular ; neurodegeneration ; Alzheimer's disease ; small vessel disease ; oxidative stress ; inflammation ; gut microbiota OECD category Physiology (including cytology) R&D Projects LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA20-00546S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UOCHB-X - RVO:61388963 UT WOS 001049127500001 EID SCOPUS 85167653214 DOI 10.33549/physiolres.935109 Annotation The worldwide increase in the incidence of obesity and cardiovascular and neurodegenerative diseases, e.g. Alzheimer's disease, is related to many factors, including an unhealthy lifestyle and aging populations. However, the interconnection between these diseases is not entirely clear, and it is unknown whether common mechanisms underlie these conditions. Moreover, there are currently no fully effective therapies for obesity and neurodegeneration. While there has been extensive research in preclinical models addressing these issues, the experimental findings have not been translated to the clinic. Another challenge relates to the time of onset of individual diseases, which may not be easily identified, since there are no specific indicators or biomarkers that define disease onset. Hence knowing when to commence preventive treatment is unclear. This is especially pertinent in neurodegenerative diseases, where the onset of the disease may be subtle and occur decades before the signs and symptoms manifest. In metabolic and cardiovascular disorders, the risk may occur in-utero, in line with the concept of fetal programming. This review provides a brief overview of the link between obesity, cardiovascular and neurodegenerative diseases and discusses potential common mechanisms including the role of the gut microbiome. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2024 Electronic address https://doi.org/10.33549/physiolres.935109
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