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RNA modification m6Am: the role in cardiac biology
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SYSNO ASEP 0573684 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title RNA modification m6Am: the role in cardiac biology Author(s) Benák, Daniel (FGU-C)
Kolář, František (FGU-C) RID, ORCID, SAI
Zhang, L. (LU)
Devaux, Y. (LU)
Hlaváčková, Markéta (FGU-C) RID, ORCIDArticle number 2218771 Source Title Epigenetics. - : Taylor & Francis - ISSN 1559-2294
Roč. 18, č. 1 (2023)Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords heart ; epitranscriptomics ; N6,2‘-O-dimethyladenosine ; m6Am ; N6-methyladenosine ; m6A OECD category Physiology (including cytology) R&D Projects GJ19-04790Y GA ČR - Czech Science Foundation (CSF) LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 001009873400001 EID SCOPUS 85163163727 DOI 10.1080/15592294.2023.2218771 Annotation Epitranscriptomic modifications have recently emerged into the spotlight of researchers due to their vast regulatory effects on gene expression and thereby cellular physiology and pathophysiology. N6,2‘-O-dimethyladenosine (m6Am) is one of the most prevalent chemical marks on RNA and is dynamically regulated by writers (PCIF1, METTL4) and erasers (FTO). The presence or absence of m6Am in RNA affects mRNA stability, regulates transcription, and modulates pre-mRNA splicing. Nevertheless, its functions in the heart are poorly known. This review summarizes the current knowledge and gaps about m6Am modification and its regulators in cardiac biology. It also points out technical challenges and lists the currently available techniques to measure m6Am. A better understanding of epitranscriptomic modifications is needed to improve our knowledge of the molecular regulations in the heart which may lead to novel cardioprotective strategies. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2024 Electronic address https://doi.org/10.1080/15592294.2023.2218771
Number of the records: 1