Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors

Skácel, Jan; Djukic, Stefan; Baszczyňski, Ondřej; Kalčic, Filip; Bílek, Tadeáš; Chalupský, Karel; Kozák, Jaroslav; Dvořáková, Alexandra; Tloušťová, Eva; Kráľová, Zuzana; Šmídková, Markéta; Voldřich, Jan; Rumlová, M.; Pachl, Petr; Brynda, Jiří; Vučková, Tereza; Fábry, Milan; Snášel, Jan; Pichová, Iva; Řezáčová, Pavlína; Mertlíková-Kaiserová, Helena; Janeba, Zlatko

doi:https://dx.doi.org/10.1021/acs.jmedchem.2c02097

Number of the records: 1

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors

1.

SYSNO	0572565
Title	Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
Author(s)	Skácel, Jan (UOCHB-X) [340/34]_{ORCID, RID} Djukic, Stefan (UOCHB-X) [930/93]_ORCID Baszczyňski, Ondřej (UOCHB-X) [910/91]_{RID, ORCID} Kalčic, Filip (UOCHB-X) [340/34]_{RID, ORCID} Bílek, Tadeáš (UOCHB-X) [980/98] Chalupský, Karel (UOCHB-X) [980/98] Kozák, Jaroslav (UOCHB-X) [980/98]_{RID, ORCID} Dvořáková, Alexandra (UOCHB-X) [980/98] Tloušťová, Eva (UOCHB-X) [980/98]_{RID, ORCID} Kráľová, Zuzana (UOCHB-X) [280/28] Šmídková, Markéta (UOCHB-X) [980/98]_{RID, ORCID} Voldřich, Jan (UOCHB-X) [980/98] Rumlová, M. (CZ) Pachl, Petr (UOCHB-X) [930/93]_{RID, ORCID} Brynda, Jiří (UOCHB-X) [930/93]_{RID, ORCID} Vučková, Tereza (UOCHB-X) [930/93] Fábry, Milan (UOCHB-X) [930/93] Snášel, Jan (UOCHB-X) [240/24]_RID Pichová, Iva (UOCHB-X) [240/24]_{RID, ORCID} Řezáčová, Pavlína (UOCHB-X) [930/93]_{RID, ORCID} Mertlíková-Kaiserová, Helena (UOCHB-X) [980/98]_{RID, ORCID} Janeba, Zlatko (UOCHB-X) [340/34]_{RID, ORCID}
Corespondence/senior	Řezáčová, Pavlína - Korespondující autor Mertlíková-Kaiserová, Helena - Korespondující autor Janeba, Zlatko - Korespondující autor
Source Title	Journal of Medicinal Chemistry. Roč. 66, č. 10 (2023), s. 6652-6681. - : American Chemical Society
Document Type	Článek v odborném periodiku
Grant	TN01000013 GA TA ČR - Technology Agency of the Czech Republic (TA ČR), CZ - Czech Republic
	EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS), CZ - Czech Republic
	LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UOCHB-X - RVO:61388963
Language	eng
Country	US
Keywords	multisubstrate analog inhibitors * transition-state analog * human erythrocytes
Cooperating institutions	Univerzita Karlova v Praze (Czech Republic) Vysoká škola chemicko-technologická v Praze (Czech Republic)
URL	https://doi.org/10.1021/acs.jmedchem.2c02097
Permanent Link	https://hdl.handle.net/11104/0343213

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Number of the records: 1