Bystander activation in memory and antigen- inexperienced memory-like CD8 T cells

0570976 - ÚMG 2024 RIV GB eng J - Journal Article
Paprčková, Darina - Šályová, Eva - Michálik, Juraj - Štěpánek, Ondřej
Bystander activation in memory and antigen- inexperienced memory-like CD8 T cells.
Current Opinion in Immunology. Roč. 82, JUN (2023), č. článku 102299. ISSN 0952-7915. E-ISSN 1879-0372
R&D Projects: GA ČR GA22-18046S; GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:68378050
Keywords : COGNATE ANTIGEN * INNATE-LIKE * MICE * INDUCTION * PHENOTYPE * IMMUNITY * ABSENCE
OECD category: Immunology
Impact factor: 7, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0952791523000183?via%3Dihub

Antigen-induced memory T cells undergo counterintuitive activation in an antigen-independent manner, which is called bystander response. Although it is well documented that memory CD8+ T cells produce IFN gamma and upregulate the cytotoxic program upon the stimulation with inflammatory cytokines, there is only rare evidence that this provides an actual protection against pathogens in immunocompetent individuals. One of the reasons might be numerous antigen-inexperienced memory-like T cells that are also capable of the bystander response. Little is known about the bystander protection of memory and memory-like T cells and their redundancies with innate-like lymphocytes in humans because of the interspecies differences and the lack of controlled experiments. However, it has been proposed that IL-15/ NKG2D-driven bystander activation of memory T cells drives protection or immunopathology in particular human diseases.
Permanent Link: https://hdl.handle.net/11104/0342304