The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK-801 model of schizophrenia-like cognitive inflexibility

Patrono, Enrico; Hrůzová, Karolína; Svoboda, Jan; Stuchlík, Aleš

doi:https://dx.doi.org/10.1016/j.schres.2022.12.047

Number of the records: 1

The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK-801 model of schizophrenia-like cognitive inflexibility

1.

SYSNO ASEP	0570434
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK-801 model of schizophrenia-like cognitive inflexibility
Author(s)	Patrono, Enrico (FGU-C)_{ORCID, SAI, RID} Hrůzová, Karolína (FGU-C)_ORCID Svoboda, Jan (FGU-C)_{RID, ORCID} Stuchlík, Aleš (FGU-C)_{RID, ORCID}
Source Title	Schizophrenia Research. - : Elsevier - ISSN 0920-9964 Roč. 252, February (2023), s. 198-205
Number of pages	8 s.
Language	eng - English
Country	NL - Netherlands
Keywords	MK-801 ; attentional set-shifting task ; excitatory/inhibitory ratio ; gamma waves ; theta waves
OECD category	Neurosciences (including psychophysiology
R&D Projects	GF21-16667K GA ČR - Czech Science Foundation (CSF)
	EF19_074/0016409 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Limited access
Institutional support	FGU-C - RVO:67985823
UT WOS	000992372700001
EID SCOPUS	85146331734
DOI	10.1016/j.schres.2022.12.047
Annotation	Schizophrenia research has increased in recent decades and focused more on its neural basis. Decision-making and cognitive flexibility are the main cognitive functions that are impaired and considered schizophrenia endophenotypes. Cognitive impairment was recently connected with altered functions of N-methyl-d-aspartate (NMDAR) glutamatergic receptors, which increased cortical activity. Selective NMDAR antagonists, such as MK-801, have been used to model cognitive inflexibility in schizophrenia. Decreased GABAergic inhibitory activity has been shown elsewhere with enhanced cortical activity. This imbalance in the excitatory/inhibitory may reduce the entrainment of prefrontal gamma and hippocampal theta rhythms and result in gamma/theta band de-synchronization.The current study established an acute MK-801 administration model of schizophrenia-like cognitive inflexibility in rats and used the attentional set-shifting task in which rats learned to switch/reverse the relevant rule. During the task, we used in vivo optogenetic stimulations of parvalbumin-positive interneurons at specific light pulses in the prefrontal cortex and ventral hippocampus.The first experiments showed that acute dizocilpine in rats produced schizophrenia-like cognitive inflexibility. The second set of experiments demonstrated that specific optogenetic stimulation at specific frequencies of parvalbumin-positive interneurons in the prefrontal cortex and ventral hippocampus rescued the cognitive flexibility rats that received acute MK-801.These findings advance our knowledge of the pivotal role of parvalbumin interneurons in schizophrenia-like cognitive impairment and may guide further research on this severe psychiatric disorder.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2024
Electronic address	https://doi.org/10.1016/j.schres.2022.12.047

Number of the records: 1