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Advanced Tool for Chiral Separations of Anionic and Zwitterionic (Metalla)carboranes: Supercritical Fluid Chromatography
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SYSNO ASEP 0566035 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Advanced Tool for Chiral Separations of Anionic and Zwitterionic (Metalla)carboranes: Supercritical Fluid Chromatography Author(s) Horáček, O. (CZ)
Nováková, L. (CZ)
Tüzün, Ece Zeynep (UACH-T) ORCID, RID, SAI
Grüner, Bohumír (UACH-T) RID, SAI, ORCID
Švec, F. (CZ)
Kučera, R. (CZ)Number of authors 6 Source Title Analytical Chemistry. - : American Chemical Society - ISSN 0003-2700
Roč. 94, č. 50 (2022), s. 17551-17558Number of pages 8 s. Language eng - English Country US - United States Keywords Anions ; Cobalt ; Mixtures ; Reaction products ; Selectivity Subject RIV CA - Inorganic Chemistry OECD category Inorganic and nuclear chemistry R&D Projects GA21-14409S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UACH-T - RVO:61388980 UT WOS 000893797700001 EID SCOPUS 85143878207 DOI 10.1021/acs.analchem.2c03895 Annotation The continuous expansion of research in the field of stable carboranes and their wide potential in the drug design require carrying out fundamental studies regarding their chiral separations. Although supercritical fluid chromatography (SFC) is a viable technique for fast enantioseparations, no investigation concerning boron cluster compounds has been done yet. We aimed at the development of a straightforward method enabling chiral separations of racemic mixtures of anionic cluster carboranes and metallacarboranes that represent an analytical challenge. The fast gradient screening testing nine polysaccharide-based columns was used. The key parameters affecting the selectivity were the type of chiral selector, the type of alcohol, and the base in cosolvent. Moreover, the addition of acetonitrile or water to the cosolvent was identified as an effective tool for decreasing the analysis time while preserving the resolution. After the optimization, the chiral separations of 19 out of 20 selected compounds were achieved in less than 10 min. These results demonstrate the clear advantage of SFC over chiral separations using HPLC in terms of both analysis time and structural variety of successfully separated compounds. Workplace Institute of Inorganic Chemistry Contact Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Year of Publishing 2023 Electronic address https://doi.org/10.1021/acs.analchem.2c03895
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