Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense

0565101 - BC 2023 RIV GB eng J - Journal Article
Horáková, Eva - Lecordier, L. - Cunha, P. - Sobotka, Roman - Changmai, Piya - Langedijk, Catharina J. M. - Van den Abbeele, J. - Vanhollebeke, B. - Lukeš, Julius
Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense.
Nature Communications. Roč. 13, č. 1 (2022), č. článku 7075. E-ISSN 2041-1723
R&D Projects: GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GA20-07186S; GA ČR(CZ) GA21-09283S; GA MŠMT(CZ) LL1601
Institutional support: RVO:60077344 ; RVO:61388971
Keywords : trypanosome * hemoglobin * evolutionary
OECD category: Microbiology; Microbiology (MBU-M)
Impact factor: 16.6, year: 2022
Method of publishing: Open access
https://www.nature.com/articles/s41467-022-34501-4

Decreased functionality and expression of trypanosome haptoglobin-hemoglobin receptor (HpHbR) is one of the evolutionary modifications that have allowed Trypanosoma brucei gambiense to infect humans. Here, Horakova et al. show that hemoglobin uptake in African trypanosomes is mediated almost exclusively by HpHbR and relevant for slender-to-stumpy differentiation. T. b. gambiense is poorly competent to differentiate into stumpy forms compared to T. b. brucei, due to reduced functionality of HpHbR.
Permanent Link: https://hdl.handle.net/11104/0339295