Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids

Szczurowska, Ewa; Szánti-Pintér, Eszter; Randáková, Alena; Jakubík, Jan; Kudová, Eva

doi:https://dx.doi.org/10.3390/ijms232113075

Number of the records: 1

Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids

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SYSNO ASEP	0564844
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids
Author(s)	Szczurowska, Ewa (UOCHB-X) Szánti-Pintér, Eszter (UOCHB-X)_ORCID Randáková, Alena (FGU-C)_{RID, ORCID} Jakubík, Jan (FGU-C)_{RID, ORCID} Kudová, Eva (UOCHB-X)_{RID, ORCID}
Article number	13075
Source Title	International Journal of Molecular Sciences. - : MDPI Roč. 23, č. 21 (2022)
Number of pages	18 s.
Language	eng - English
Country	CH - Switzerland
Keywords	neurosteroids ; neuroactive steroids ; cholesterol ; muscarinic receptors ; allosteric modulation
OECD category	Biochemistry and molecular biology
R&D Projects	LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	UOCHB-X - RVO:61388963 ; FGU-C - RVO:67985823
UT WOS	000881456100001
EID SCOPUS	85141881537
DOI	10.3390/ijms232113075
Annotation	Muscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurosteroids, neuroactive steroids, and steroid hormones are molecules of steroid origin that, besides having well-known genomic effects, also modulate membrane proteins including muscarinic acetylcholine receptors. Here, we review current knowledge on the allosteric modulation of muscarinic receptors by these steroids. We give a perspective on the research on the non-genomic effects of steroidal compounds on muscarinic receptors and drug development, with an aim to ultimately exploit such knowledge.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2023
Electronic address	https://doi.org/10.3390/ijms232113075

Number of the records: 1