Number of the records: 1
Pharmacokinetics of intramuscularly administered thermoresponsive polymers
- 1.
SYSNO ASEP 0564350 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Pharmacokinetics of intramuscularly administered thermoresponsive polymers Author(s) Groborz, Ondřej (UMCH-V) ORCID, RID
Kolouchová, Kristýna (UMCH-V) ORCID, RID
Pankrác, J. (CZ)
Keša, P. (CZ)
Kadlec, J. (IL)
Krunclová, Tereza (UMCH-V) ORCID
Pierzynová, A. (CZ)
Šrámek, J. (CZ)
Hovořáková, M. (CZ)
Dalecká, L. (CZ)
Pavlíková, Z. (CZ)
Matouš, P. (CZ)
Páral, P. (CZ)
Loukotová, L. (CZ)
Švec, P. (CZ)
Beneš, Hynek (UMCH-V) RID, ORCID
Štěpánek, L. (CZ)
Dunlop, D. (CZ)
Melo, C. V. (CZ)
Šefc, L. (CZ)
Slanina, T. (CZ)
Beneš, J. (CZ)
van Vlierberghe, S. (BE)
Hoogenboom, R. (BE)
Hrubý, Martin (UMCH-V) RID, ORCIDArticle number 2201344 Source Title Advanced Healthcare Materials. - : Wiley - ISSN 2192-2640
Roč. 11, č. 22 (2022)Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords biodistribution ; LCST ; poly(2,2-difluoroethyl)acrylamide Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects TO01000074 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) LTC19032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA21-04166S GA ČR - Czech Science Foundation (CSF) Research Infrastructure Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i. Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000879463300001 EID SCOPUS 85141470993 DOI 10.1002/adhm.202201344 Annotation Aqueous solutions of some polymers exhibit a lower critical solution temperature (LCST), that is, they form phase-separated aggregates when heated above a threshold temperature. Such polymers found many promising (bio)medical applications, including in situ thermogelling with controlled drug release, polymer-supported radiotherapy (brachytherapy), immunotherapy, and wound dressing, among others. Yet, despite the extensive research on medicinal applications of thermoresponsive polymers, their biodistribution and fate after administration remained unknown. Thus, herein, they studied the pharmacokinetics of four different thermoresponsive polyacrylamides after intramuscular administration in mice. In vivo, these thermoresponsive polymers formed depots that subsequently dissolved with a two-phase kinetics (depot maturation, slow redissolution) with half-lives 2 weeks to 5 months, as depot vitrification prolonged their half-lives. Additionally, the decrease of TCP of a polymer solution increased the density of the intramuscular depot. Moreover, they detected secondary polymer depots in the kidneys and liver, these secondary depots also followed two-phase kinetics (depot maturation and slow dissolution), with half-lives 8 to 38 days (kidneys) and 15 to 22 days (liver). Overall, these findings may be used to tailor the properties of thermoresponsive polymers to meet the demands of their medicinal applications. Their methods may become a benchmark for future studies of polymer biodistribution.
Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2023 Electronic address https://onlinelibrary.wiley.com/doi/10.1002/adhm.202201344
Number of the records: 1