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Synthesis of 19F MRI nanotracers by dispersion polymerization-induced self-assembly of N-(2,2,2-trifluoroethyl)acrylamide in water
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SYSNO ASEP 0563955 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis of 19F MRI nanotracers by dispersion polymerization-induced self-assembly of N-(2,2,2-trifluoroethyl)acrylamide in water Author(s) Panakkal, V. M. (CZ)
Havlíček, D. (CZ)
Pavlova, Ewa (UMCH-V) RID
Filipová, Marcela (UMCH-V) RID, ORCID
Bener, S. (CZ)
Jirák, D. (CZ)
Sedláček, O. (CZ)Source Title Biomacromolecules. - : American Chemical Society - ISSN 1525-7797
Roč. 23, č. 11 (2022), s. 4814-4824Number of pages 11 s. Language eng - English Country US - United States Keywords polymerization-induced self-assembly ; 19F MRI ; polymer tracers Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects GA22-02836S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000875637500001 EID SCOPUS 85140322010 DOI 10.1021/acs.biomac.2c00981 Annotation 19F magnetic resonance imaging (MRI) using fluoropolymer tracers has recently emerged as a promising, non-invasive diagnostic tool in modern medicine. However, despite its potential, 19F MRI remains overlooked and underused due to the limited availability or unfavorable properties of fluorinated tracers. Herein, we report a straightforward synthetic route to highly fluorinated 19F MRI nanotracers via aqueous dispersion polymerization-induced self-assembly of a water-soluble fluorinated monomer. A polyethylene glycol-based macromolecular chain-transfer agent was extended by RAFT-mediated N-(2,2,2-trifluoroethyl)acrylamide (TFEAM) polymerization in water, providing fluorine-rich self-assembled nanoparticles in a single step. The resulting nanoparticles had different morphologies and sizes ranging from 60 to 220 nm. After optimizing their structure to maximize the magnetic relaxation of the fluorinated core, we obtained a strong 19F NMR/MRI signal in an aqueous environment. Their non-toxicity was confirmed on primary human dermal fibroblasts. Moreover, we visualized the nanoparticles by 19F MRI, both in vitro (in aqueous phantoms) and in vivo (after subcutaneous injection in mice), thus confirming their biomedical potential. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2023 Electronic address https://pubs.acs.org/doi/10.1021/acs.biomac.2c00981
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