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Iron-oxide minerals in the human tissues
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SYSNO ASEP 0560645 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Iron-oxide minerals in the human tissues Author(s) Svobodová, H. (SK)
Kosnáč, D. (SK)
Tanila, H. (FI)
Wagner, A. (SK)
Trnka, M. (SK)
Vitovic, P. (SK)
Hlinková, Jana (UEM-P)
Vavrinsky, E. (SK)
Ehrlich, H. (DE)
Polák, S. (SK)
Kopáni, M. (SK)Source Title Biometals. - : Springer - ISSN 0966-0844
Roč. 33, č. 1 (2020), s. 1-13Number of pages 13 s. Language eng - English Country GB - United Kingdom Keywords iron oxides ; ferritin ; human tissues ; biomineralization OECD category Biomaterials (as related to medical implants, devices, sensors) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000508702600001 EID SCOPUS 85078130566 DOI 10.1007/s10534-020-00232-6 Annotation Iron is critically important and highly regulated trace metal in the human body. However, in its free ion form, it is known to be cytotoxic, therefore, it is bound to iron storing protein, ferritin. Ferritin is a key regulator of body iron homeostasis able to form various types of minerals depending on the tissue environment. Each mineral, e.g. magnetite, maghemite, goethite, akaganeite or hematite, present in the ferritin core carry different characteristics possibly affecting cells in the tissue. In specific cases, it can lead to disease development. Widely studied connection with neurodegenerative conditions is widely studied, including Alzheimer disease. Although the exact ferritin structure and its distribution throughout a human body are still not fully known, many studies have attempted to elucidate the mechanisms involved in its regulation and pathogenesis. In this review, we try to summarize the iron uptake into the body. Next, we discuss the known occurrence of ferritin in human tissues. Lastly, we also examine the formation of iron oxides and their involvement in brain functions. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2023 Electronic address https://link.springer.com/article/10.1007/s10534-020-00232-6
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