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Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress
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SYSNO ASEP 0560559 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve SCOPUS Title Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress Author(s) Rakotoarisoa, M. (FR)
Angelov, Borislav (FZU-D) ORCID
Drechsler, M. (DE)
Nicolas, V. (FR)
Bizien, T. (FR)
Gorshkova, Yu. E. (RU)
Deng, Y. (CN)
Angelova, A. (FR)Number of authors 8 Source Title Smart Materials in Medicine. - : KeAi Publishing Communications
Roč. 3, Jan (2022), s. 274-288Number of pages 15 s. Language eng - English Country CN - China Keywords lipid liquid crystalline nanoparticles ; nanomedicine ; cubosome ; spongosome ; curcumin ; brain-derived neurotrophic factor ; neuroprotection ; endoplasmic reticulum stress Subject RIV BO - Biophysics OECD category Biophysics R&D Projects EF15_003/0000447 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF16_019/0000789 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FZU-D - RVO:68378271 EID SCOPUS 85126904679 DOI 10.1016/j.smaim.2022.03.001 Annotation We develop multidrug-loaded cubosome and spongosome lipid nanoparticles for targeting of endoplasmic reticulum stress as a potential emerging therapeutic strategy against neuronal degeneration. The multicompartment organization of the liquid crystalline nanoparticles (LCNPs), fabricated by self-assembly, was characterized by cryogenic transmission electron microscopy (cryo-TEM) and small-angle X-ray scattering (SAXS). Monoolein-based cubosome and spongosome LCNPs co-encapsulated the natural plant-derived antioxidant curcumin, fish oil rich in ω-3 polyunsaturated fatty acids (PUFA), and the neurotrophin brain-derived neurotrophic factor (BDNF), which is of vital need for neurogenesis. The neuroprotective properties of the nanoparticles were in vitro investigated in a cellular model of tunicamycin-induced endoplasmic reticulum (ER) stress using differentiated human neuroblastoma SH-SY5Y cells deprieved from serum. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2023 Electronic address https://hdl.handle.net/11104/0333429
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