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Insoluble hyaluronan films obtained by heterogeneous crosslinking with iron(III) as resorbable implants
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SYSNO ASEP 0551016 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Insoluble hyaluronan films obtained by heterogeneous crosslinking with iron(III) as resorbable implants Author(s) Mrázek, J. (CZ)
Kohout, J. (CZ)
Kmjec, T. (CZ)
Nešporová, K. (CZ)
Chmelař, J. (CZ)
Kubala, Lukáš (BFU-R) RID, ORCID
Velebný, V. (CZ)Number of authors 7 Source Title International Journal of Biological Macromolecules. - : Elsevier - ISSN 0141-8130
Roč. 191, NOV 30 2021 (2021), s. 201-210Number of pages 10 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords acid hydrogel films ; complexes ; prevention ; adhesions ; scaffolds Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology Method of publishing Limited access Institutional support BFU-R - RVO:68081707 UT WOS 000710169700004 EID SCOPUS 85115304240 DOI 10.1016/j.ijbiomac.2021.09.059 Annotation We present water-insoluble hyaluronan films crosslinked by trivalent iron developed as potential resorbable implants. The films were crosslinked by sorption of ferric salt into solid HA films in water/2-propanol bath. These heterogeneously crosslinked films (het-FeHA) remained tough and dimensionally stable when rehydrated in saline. In contrast, films prepared by drying the well-known homogeneous ferric hyaluronate gels (hom-FeHA) softened upon rehydration and expanded rapidly. Differences between hom-FeHA and het-FeHA result from polymer network topology (dominant inter-or intra-molecular crosslink, respectively). Moreover, Mossbauer spectroscopy of het-FeHA revealed diiron complexes, while iron in the hom-FeHA was present exclusively as gamma-FeOOH nanoparticles or amorphous FeOOH. The biocompatibility tests of het-FeHA did not show any adverse effect and the sample disintegrated within one day when implanted in mice peritoneum. In conclusion, we developed implantable hyaluronan-based free-standing film with minimal swelling that can be resorbed quickly enough to avoid induction of foreign-body reaction. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2022 Electronic address https://www.sciencedirect.com/science/article/pii/S0141813021019802?via%3Dihub
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