Number of the records: 1
Tumor vessel co-option probed by single-cell analysis
- 1.
SYSNO ASEP 0550598 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Tumor vessel co-option probed by single-cell analysis Author(s) Teuwen, L.-A. (BE)
De Rooij, L. P. M. H. (BE)
Cuypers, A. (BE)
Rohlenová, Kateřina (BTO-N) ORCID, RID
Dumas, S. J. (BE)
Garcia-Caballero, M. (ES)
Meta, E. (BE)
Amersfoort, J. (BE)
Taverna, F. (BE)
Becker, L. M. (BE)
Veiga, N. (BE)
Cantelmo, A. R. (BE)
Geldhof, V. (BE)
Conchinha, N. (BE)
Kalucka, J. (BE)
Treps, L. (BE)
Conradi, L.-Ch. (BE)
Khan, S. (BE)
Karakach, T. K. (BE)
Soenen, S. (BE)
Vinckier, S. (BE)
Schoonjans, L. (BE)
Eelen, G. (BE)
Van Laere, S. (BE)
Dewerchin, M. (BE)
Dirix, L. (BE)
Mazzone, M. (BE)
Luo, Y. (CN)
Vermeulen, P. (BE)
Carmeliet, P. (BE)Number of authors 30 Article number 109253 Source Title Cell Reports. - : Cell Press - ISSN 2211-1247
Roč. 35, č. 11 (2021)Number of pages 29 s. Language eng - English Country GB - United Kingdom Keywords anti-angiogenic therapy ; epithelium-derived factor ; cancer liver metastases ; smooth-muscle-cells ; gene-expression ; pdgf-b Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology Method of publishing Open access Institutional support BTO-N - RVO:86652036 UT WOS 000661869600013 EID SCOPUS 85107954184 DOI 10.1016/j.celrep.2021.109253 Annotation Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer andmyeloid cells in tumors growing via vessel co-option, has not been investigated at the single-cell level. Here, we use a murine AAT-resistant lung tumor model, in which VEGF-targeting induces vessel co-option for continued growth. Single-cell RNA sequencing (scRNA-seq) of 31,964 cells reveals, unexpectedly, a largely similar transcriptome of co-opted tumor ECs (TECs) and pericytes as their healthy counterparts. Notably, we identify cell types that might contribute to vessel co-option, i.e., an invasive cancer-cell subtype, possibly assisted by a matrix-remodeling macrophage population, and another M1-like macrophage subtype, possibly involved in keeping or rendering vascular cells quiescent. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2022 Electronic address https://www.sciencedirect.com/science/article/pii/S2211124721006185?via%3Dihub
Number of the records: 1