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Microdevices for Cell Stimulation: Integrated Zinc Oxide Piezoelectric Nanostructures in Silicon Microparticles
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SYSNO ASEP 0549811 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Microdevices for Cell Stimulation: Integrated Zinc Oxide Piezoelectric Nanostructures in Silicon Microparticles Author(s) Lefaix, L. (ES)
Blanquer, Andreu (FGU-C) RID, ORCID
Bačáková, Lucie (FGU-C) RID, ORCID
Esteve, J. (ES)
Murillo, G. (ES)Source Title 34th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2021. - New York : IEEE, 2021 - ISBN 978-1-6654-1912-3 Pages s. 559-562 Number of pages 4 s. Publication form Online - E Action International Conference on Micro Electro Mechanical Systems (MEMS) /34./ Event date 25.01.2021 - 29.01.2021 VEvent location Gainesville Country US - United States Event type WRD Language eng - English Country US - United States Keywords piezoelectricity ; NG ; ZnO ; NS ; microdevice ; bioelectronics ; cell stimulation ; biomaterial Subject RIV EI - Biotechnology ; Bionics OECD category Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction) R&D Projects GA20-01570S GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000667731600137 EID SCOPUS 85103434691 DOI 10.1109/MEMS51782.2021.9375134 Annotation Bioelectronic medicine is acquiring importance within the field of regenerative medicine. Several types of cells migrate, differentiate or proliferate in response to electrical stimuli, promoting tissue regeneration. Piezoelectric nanogenerators (NGs) are capable of electrically stimulate cells in a wireless way through acoustic power, broadening the scope of materials used for biomedical applications.In this work, microdevices consisting of piezoelectric zinc oxide nanosheets (ZnO NSs) integrated on silicon microparticles were synthesized. Finite element modelling (FEM) simulations demonstrate that these microdevices are able to produce electric fields (EF) in response to mechanical stresses or ultrasonic waves. In vitro testing with osteoblast Saos-2 cells proved their cytocompatibility. Soon, the use of these simple, costless and technologically reproducible microdevices may offer new ways to develop bioelectronic therapies. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2022 Electronic address https://ieeexplore.ieee.org/document/9375134
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