Direct comparison of analogous amphiphilic gradient and block polyoxazolines

Loukotová, Lenka; Švec, Pavel; Groborz, Ondřej; Heizer, T.; Beneš, Hynek; Raabová, Helena; Bělinová, T.; Herynek, V.; Hrubý, Martin

doi:https://dx.doi.org/10.1021/acs.macromol.0c02674

Number of the records: 1

Direct comparison of analogous amphiphilic gradient and block polyoxazolines

1.

SYSNO ASEP	0545562
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Direct comparison of analogous amphiphilic gradient and block polyoxazolines
Author(s)	Loukotová, Lenka (UMCH-V)_{RID, ORCID} Švec, Pavel (UMCH-V)_{RID, ORCID} Groborz, Ondřej (UMCH-V)_{ORCID, RID} Heizer, T. (CZ) Beneš, Hynek (UMCH-V)_{RID, ORCID} Raabová, Helena (UMG-J) Bělinová, T. (CZ) Herynek, V. (CZ) Hrubý, Martin (UMCH-V)_{RID, ORCID}
Source Title	Macromolecules. - : American Chemical Society - ISSN 0024-9297 Roč. 54, č. 17 (2021), s. 8182-8194
Number of pages	13 s.
Language	eng - English
Country	US - United States
Keywords	poly-2-phenyl-2-oxazoline ; gradient polymer ; polymerization kinetics
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
Subject RIV - cooperation	Institute of Molecular Genetics - Genetics ; Molecular Biology
R&D Projects	GA19-01602S GA ČR - Czech Science Foundation (CSF)
	LTC19032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LM2015062 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LM2018129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	EF16_013/0001775 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Research Infrastructure	Czech-BioImaging - 90062 - Ústav molekulární genetiky AV ČR, v. v. i. Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013 ; UMG-J - RVO:68378050
UT WOS	000697107700049
EID SCOPUS	85112693409
DOI	10.1021/acs.macromol.0c02674
Annotation	Both gradient and block copolymers can be used as drug delivery systems, but their relative (dis)advantages remain unknown. Thus, we directly compared analogous amphiphilic gradient and block polyoxazolines for their physicochemical properties and potential as building components of nanodrugs. For this purpose, we prepared a library of 18 polymers with varying ratios of monomeric units, using 2-methyl-2-oxazoline (MeOx) as a hydrophilic monomer and 2-phenyl-2-oxazoline (PhOx), 2-(4-butylphenyl)-2-oxazoline (BuPhOx), or 2-(4-butoxyphenyl)-2-oxazoline (BuOPhOx) as a hydrophobic monomer, and determined their homo/heteropolymerization kinetics. Our results showed that gradient copolymers had broader glass transition intervals and formed nanoparticles several times smaller and more compact than the corresponding block analogs. In particular, PMeOx70-grad-PhOx30 and PMeOx70-grad-BuPhOx30 exhibited a significantly higher drug loading capacity and entrapment efficiency than their corresponding block analogs. Notwithstanding these differences, all polymers were cyto- and hemocompatible in vitro. Therefore, analogous gradient and block copolymers may be alternatively used for specific biomedical applications.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2022
Electronic address	https://pubs.acs.org/doi/10.1021/acs.macromol.0c02674

Number of the records: 1