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Gas aggregated Ag nanoparticles as the inorganic matrix for laser desorption/ionization mass spectrometry
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SYSNO ASEP 0541682 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Gas aggregated Ag nanoparticles as the inorganic matrix for laser desorption/ionization mass spectrometry Author(s) Kratochvíl, Jiří (FZU-D) ORCID
Prysiazhnyi, V. (CZ)
Dyčka, F. (CZ)
Kylián, O. (CZ)
Kúš, P. (CZ)
Sezemský, P. (CZ)
Štěrba, Ján (BC-A) RID, ORCID
Straňák, Vítězslav (FZU-D) RID, ORCIDNumber of authors 8 Article number 148469 Source Title Applied Surface Science. - : Elsevier - ISSN 0169-4332
Roč. 541, Mar (2021)Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords gas aggregation source ; nanoparticles ; laser desorption/ionization time-of-flight mass spectrometry Subject RIV BL - Plasma and Gas Discharge Physics OECD category Fluids and plasma physics (including surface physics) Subject RIV - cooperation Biology Centre (since 2006) - Microbiology, Virology R&D Projects EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support FZU-D - RVO:68378271 ; BC-A - RVO:60077344 UT WOS 000608511200005 EID SCOPUS 85096515703 DOI 10.1016/j.apsusc.2020.148469 Annotation We report here on a nanoparticle-assisted laser desorption/ionization time-of-flight mass spectrometry (NP-LDI-TOF MS) for the detection of small molecules. This technique is based on the overcoating of a dried analyte by an array of silver nanoparticles produced by gas aggregation source. This allows for the spatially homogeneous distribution of nanoparticles over the analyte that may fully substitute a conventional organic matrix routinely used for the matrix-assisted laser desorption/ionization mass spectrometry and thus limit the possible interference of matrix with the low-mass molecules. Furthermore, it is shown that the intensity of the detected signal strongly correlates with the number of deposited Ag nanoparticles. At its optimum, that was found to correspond to the nanoparticle surface density of 3x10(3) NPs.mu m(-2), the detection limit was 3x10(-8) g.L-1 for riboflavin. Such a high detection limit, together with good reproducibility, excellent signal stability, and imaging capability, makes this technique a valuable alternative to other laser desorption/ionization-based detection methods. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2022 Electronic address https://doi.org/10.1016/j.apsusc.2020.148469
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