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The actin regulator profilin 1 is functionally associated with the mammalian centrosome
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SYSNO ASEP 0540121 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The actin regulator profilin 1 is functionally associated with the mammalian centrosome Author(s) Nejedlá, M. (SE)
Klebanovych, Anastasiya (UMG-J)
Sulimenko, Vadym (UMG-J) RID, ORCID
Sulimenko, Tetyana (UMG-J)
Dráberová, Eduarda (UMG-J) RID, ORCID
Dráber, Pavel (UMG-J) RID, ORCID
Karlsson, R. (SE)Article number e202000655 Source Title Life Science Alliance. - : Life Science Alliance
Roč. 4, č. 1 (2021)Number of pages 8 s. Publication form Online - E Language eng - English Country US - United States Keywords profilin ; centrosome ; microtubule nucleation Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects GA18-27197S GA ČR - Czech Science Foundation (CSF) LM2018129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000614606300003 DOI 10.26508/lsa.202000655 Annotation Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2023 Electronic address https://www.life-science-alliance.org/content/4/1/e202000655
Number of the records: 1