Magnetic nanoparticles of Ga-substituted ε-Fe.sub.2./sub.O.sub.3./sub. for biomedical applications: magnetic properties, transverse relaxivity, and effects of silica-coated particles on cytoskeletal networks

0532459 - FZÚ 2021 RIV US eng J - Journal Article
Královec, K. - Havelek, R. - Koutová, D. - Veverka, Pavel - Kubíčková, Lenka - Brázda, Petr - Kohout, J. - Herynek, V. - Vosmanská, M. - Kaman, Ondřej
Magnetic nanoparticles of Ga-substituted ε-Fe₂O₃ for biomedical applications: magnetic properties, transverse relaxivity, and effects of silica-coated particles on cytoskeletal networks.
Journal of Biomedical Materials Research. Part A. Roč. 108, č. 7 (2020), s. 1563-1578. ISSN 1549-3296. E-ISSN 1552-4965
R&D Projects: GA MŠMT(CZ) EF16_019/0000760; GA ČR GA18-13323S
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : cytoskeleton * cytotoxicity * epsilon polymorph * Ga-doped iron(III) oxide * transverse relaxivity
OECD category: Nano-materials (production and properties)
Impact factor: 4.396, year: 2020
Method of publishing: Limited access
https://doi.org/10.1002/jbm.a.36926

Magnetic nanoparticles of epsilon-Fe1.76Ga0.24O3 with the volume-weighted mean size of 17 nm were prepared by thermal treatment of a mesoporous silica template impregnated with metal nitrates and were coated with silica shell of four different thicknesses in the range 6-24 nm. The bare particles exhibited higher magnetization than the undoped compound, 22.4 Am-2 kg-1 at 300 K, and were characterized by blocked state with the coercivity of 1.2 T at 300 K. The relaxometric study of the silica-coated samples at 0.47 T revealed promising properties for MRI, specifically, transverse relaxivity of 89-168 s-1mmol(f)-1L depending on the shell thickness was observed. We investigated the effects of the silica-coated nanoparticles on human A549 and MCF-7 cells. Cell viability, proliferation, cell cycle distribution, and the arrangement of actin cytoskeleton were assessed, as well as formation and maturation of focal adhesions.
Permanent Link: http://hdl.handle.net/11104/0310945