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Physical study of proton therapy at CANAM laboratory on medulloblastoma cell lines DAOY
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SYSNO ASEP 0531352 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Physical study of proton therapy at CANAM laboratory on medulloblastoma cell lines DAOY Author(s) Torrisi, L. (IT)
Davídková, Marie (UJF-V) RID, ORCID, SAI
Cutroneo, Mariapompea (UJF-V) ORCID, RID, SAI
Torrisi, Alfio (UJF-V) RID, ORCIDNumber of authors 4 Source Title Radiation Effects and Defects in Solids. - : Taylor & Francis - ISSN 1042-0150
Roč. 175, 9-10 (2020), s. 863-878Number of pages 16 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords protontherapy ; Bragg peak ; medulloblastoma cell line DAOY ; proton dose Subject RIV FP - Other Medical Disciplines OECD category Radiology, nuclear medicine and medical imaging R&D Projects LM2015056 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GBP108/12/G108 GA ČR - Czech Science Foundation (CSF) GA19-02482S GA ČR - Czech Science Foundation (CSF) EF16_013/0001812 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support UJF-V - RVO:61389005 UT WOS 000547485400001 EID SCOPUS 85087367863 DOI 10.1080/10420150.2020.1780592 Annotation 2.0 MeV proton beam accelerated at Tandetron is extracted in air through a thin film and allowed to scatter to irradiate the cell culture attached to the polymeric base of a biological flask. The irradiated cells were human medulloblastoma cell line Daoy treated with and without 5 nm sized spherical gold nanoparticles. Proton doses from 0.5 to 1.5 Gy have been employed to irradiate the cultures and to investigate the role of the radiotherapy performed with and without the use of the gold nanoparticles. Results indicated that cell survival is significantly reduced to about 50% when the nanoparticles at a concentration of about 6 x 10(13)particles/ml are employed. Workplace Nuclear Physics Institute Contact Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Year of Publishing 2021 Electronic address https://doi.org/10.1080/10420150.2020.1780592
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