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Amphiphilic compounds with neuroprotective properties
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SYSNO ASEP 0519500 Document Type P - Patent R&D Document Type Patent or other outcome protected by special legislation Title Amphiphilic compounds with neuroprotective properties Author(s) Kudová, Eva (UOCHB-X) RID, ORCID
Chodounská, Hana (UOCHB-X) RID, ORCID
Kapras, Vojtěch (UOCHB-X)
Vyklický ml., Ladislav (FGU-C) RID, ORCID, SAI
Valeš, Karel (FGU-C) RID, ORCID, SAI
Jahn, Ullrich (UOCHB-X) ORCIDYear of issue 2019 Possible third party use of the result A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence Royalty requested A - Poskytovatel licence požaduje licenční poplatek Patent no. or utility model no. or industrial design no. EP3260462 Date of the patent acceptance 17.04.2019 Name of the patent owner Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i Code of the issuer name EPO_1 - European Patent Office Munich, The Hague, Berlin, Vienna, Brusselshttp://www.epo.org/ Current use A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem Language eng - English Keywords steroid ; NMDA receptor ; neuroprotective Subject RIV CC - Organic Chemistry OECD category Organic chemistry Subject RIV - cooperation Institute of Physiology - Pharmacology ; Medidal Chemistry R&D Projects TE01020028 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) Institutional support UOCHB-X - RVO:61388963 ; FGU-C - RVO:67985823 Annotation The present invention provides amphiphilic compounds with a tetradecahydrophenanthrene skeleton of formula (I), wherein R1-R5 are as defined herein, and their enantiomers, exhibiting neuroprotective effects, for use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain , addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2020 Electronic address https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20190417&DB=&locale=en_EP&CC=EP&NR=3260462B1&KC=B1&ND=5#
Number of the records: 1