The potential of memory enhancement through modulation of perineuronal nets

0518209 - ÚEM 2020 RIV GB eng J - Journal Article
Duncan, J.A. - Foster, R. - Kwok, Jessica
The potential of memory enhancement through modulation of perineuronal nets.
British Journal of Pharmacology. Roč. 176, č. 18 (2019), s. 3611-3621. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA MŠMT(CZ) EF15_003/0000419
Institutional support: RVO:68378041
Keywords : chondroitin sulfate proteoglycans * ocular dominance plasticity * extracellular-matrix
OECD category: Neurosciences (including psychophysiology
Impact factor: 7.730, year: 2019
Method of publishing: Open access
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14672

With an increasingly aging global population, the incidence of neurological diseases such as dementia is set to increase to unmanageable levels, yet there are currently only symptomatic therapies available for treatment. The mechanisms underlying the development of some forms of dementia, such as Alzheimer's disease (AD), are not yet completely elucidated with several competing hypotheses existing. During the closure of the critical period in the brain, significant compositional changes occur to the neural extracellular matrix (ECM). Specifically, condensed mesh-like structures called perineuronal nets (PNNs) form around subsets of neurons and have a profound effect on axonal growth and limit neuronal plasticity. These PNNs act as a morphological checkpoint and can influence memory and cognition. Manipulating these important ECM structures may provide the key to reactivating plasticity and restoring memory, both of which are severely impaired in AD and other associated neurological diseases. This review explores the current understanding of how PNNs are manipulated and examines potential new methods for PNN modulation. Linked Articles This article is part of a themed section on Therapeutics for Dementia and Alzheimer's Disease: New Directions for Precision Medicine. To view the other articles in this section visit
Permanent Link: http://hdl.handle.net/11104/0303575