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NanoTiO(2) Sunscreen Does Not Prevent Systemic Oxidative Stress Caused by UV Radiation and a Minor Amount of NanoTiO(2) is Absorbed in Humans
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SYSNO ASEP 0507580 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title NanoTiO(2) Sunscreen Does Not Prevent Systemic Oxidative Stress Caused by UV Radiation and a Minor Amount of NanoTiO(2) is Absorbed in Humans Author(s) Pelclová, D. (CZ)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Kačerová, T. (GB)
Zámostná, K. (CZ)
Fenclová, Z. (CZ)
Vlčková, Š. (CZ)
Kačer, P. (CZ)Article number 888 Source Title Nanomaterials. - : MDPI
Roč. 9, č. 6 (2019)Number of pages 23 s. Language eng - English Country CH - Switzerland Keywords Exhaled breath condensate (EBC) ; Inflammation ; Nanoparticles absorption ; NanoTiO 2 ; Nanotoxicology ; Oxidative stress ; Plasma Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry R&D Projects GA18-02079S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UFCH-W - RVO:61388955 UT WOS 000475352900082 EID SCOPUS 85070237976 DOI 10.3390/nano9060888 Annotation Licensee MDPI, Basel, Switzerland. The present pilot study tested the efficiency of nanoTiO2 sunscreen to prevent the oxidative stress/inflammation caused by ultraviolet (UV) radiation using biomarkers in subjects’ blood, urine, and exhaled breath condensate (EBC). In addition, the skin absorption of nanoTiO2 was studied. Six identical subjects participated in three tests: (A) nanoTiO2 sunscreen, (B)UV radiation, and (C) sunscreen +UV. The first sampleswere collected before the test and the second after sunscreen application and/or UV exposure. On day 4, the third sampleswere collected, and the sunscreenwaswashed off, and the fourth sampleswere collectedonday11. The followingbiomarkersweremeasured: malondialdehyde, 4-hydroxy-trans-hexenal, 4-hydroxy-trans-nonenal, aldehydes C6-C12, 8-iso-Prostaglandin F2α, o-tyrosine, 3-chlorotyrosine, 3-nitrotyrosine, 8-hydroxy-2-deoxyguanosine, 8-hydroxyguanosine, 5-hydroxymethyl uracil, and leukotrienes, using liquid chromatography-electrospray ionisation-tandem mass spectrometry. Titania was measured using inductively coupled plasma mass spectrometry and TiO2 nanoparticles by transmission and scanning electron microscopy. Sunscreen alone did not elevate the markers, but UV increased the biomarkers in the plasma, urine, and EBC. The sunscreen prevented skin redness, however it did not inhibit the elevation of oxidative stress/inflammatory markers. Titania and nanoTiO2 particles were found in the plasma and urine (but not in the EBC) in all sunscreen users, suggesting their skin absorption. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2020 Electronic address http://hdl.handle.net/11104/0298568
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