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Differences of Saliva Composition in Relation to Tooth Decay and Gender
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SYSNO ASEP 0505673 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Differences of Saliva Composition in Relation to Tooth Decay and Gender Author(s) Kulhavá, Lucie (FGU-C) ORCID
Eckhardt, Adam (FGU-C) RID, ORCID
Pataridis, Statis (FGU-C)
Bartoš, M. (CZ)
Foltán, R. (CZ)
Mikšík, Ivan (FGU-C) RID, ORCID, SAISource Title Folia Biologica. - : Univerzita Karlova v Praze - ISSN 0015-5500
Roč. 64, 5-6 (2018), s. 195-203Number of pages 9 s. Language eng - English Country CZ - Czech Republic Keywords dental caries ; DMFT ; gender ; saliva ; proteins Subject RIV CB - Analytical Chemistry, Separation OECD category Analytical chemistry R&D Projects NV17-31564A GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000470083200006 EID SCOPUS 85064208000 Annotation Most people worldwide suffer from dental caries. Only a small part of the population is caries-resistant and the reason for this resistance in unknown. Only a few studies compared the saliva protein composition of persons with carious teeth and persons with no caries. Our study is the first to relate proteomic analysis of the caries aetiology with gender. In this study, we compared the differences in the abundances of proteins in the saliva between caries-resistant and caries-susceptible females and males by nano-liquid chromatography-tandem mass spectrometry (Label-Free Quantitative Proteomics). Our results demonstrate that the observed differences in the protein levels might have an influence on anti-caries resistance. A total of 19 potential markers of tooth caries were found, for example proteins S100A8 and annexin A1 with higher expression in the caries-susceptible group in comparison with the caries-free group and mucin-5B, lactoferrin, lysozyme C with higher expression in the caries-free group in comparison with the caries-susceptible group. The presented study is the first complex proteomic and gender project where the saliva protein content of caries-free and caries-susceptible persons were compared by label-free MS. The newly detected potential protein markers of dental caries can be a good basis for further research and for possible future therapeutic use. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2020 Electronic address https://fb.cuni.cz/file/5885/fb2018a0024.pdf
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