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Diabetes, Cardiovascular Disorders and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Body Burden in Czech Patients 50Years After the Intoxication
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SYSNO ASEP 0492493 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Diabetes, Cardiovascular Disorders and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Body Burden in Czech Patients 50Years After the Intoxication Author(s) Pelcl, T. (CZ)
Škrha, J. (CZ)
Prázný, M. (CZ)
Vlčková, Š. (CZ)
Fenclová, Z. (CZ)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Malík, J. (CZ)
Diblík, P. (CZ)
Zikán, V. (CZ)
Pelclová, D. (CZ)Source Title Basic & Clinical Pharmacology & Toxicology. - : Wiley - ISSN 1742-7835
Roč. 123, č. 3 (2018), s. 356-359Number of pages 4 s. Language eng - English Country US - United States Keywords aryl-hydrocarbon receptor ; residential proximity ; organic pollutants ; exposure ; workers ; dioxin Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry Institutional support UFCH-W - RVO:61388955 UT WOS 000441237300019 EID SCOPUS 85046403640 DOI 10.1111/bcpt.13013 Annotation The correlation between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication and the parameters of metabolic impairment was examined in the last eight male survivors of 80 workers exposed to TCDD during the production of herbicides in a chemical factory in 1965-1967. Their median TCDD blood level was 112 (46-390) pg/g lipids, and the median TCDD body deposit was 3.9 (0.8-11.7) g. This puts these patients into the most severely intoxicated group of subjects, according to back-calculated levels of TCDD. The median TCDD blood level in eight controls was 12pg/g (<0.10 to 22.2pg/g). Markers of metabolic impairment diabetes, dyslipidaemia, arterial hypertension, carotid artery plaque, skin microvascular reactivity, eye fundus hypertensive angiopathy and history of coronary heart disease were assessed and compared to a general male population of comparable age. Measured parameters compared with a population of comparable age were as follows: prevalence of diabetes (62.5% versus 17.6%), arterial hypertension (87.5% versus 71.8%), dyslipidaemia (87.5% versus 88.8%), history of coronary heart disease (62.5% versus 26.0%) and eye fundus hypertension angiopathy (50% versus 14%). All eight patients (100% versus 43%) developed plaques in carotid arteries, six had stenosis >50% and two had a carotid intervention (stenting or endarterectomy). Total cholesterol levels decreased compared to the earlier study this patient group in 2008, most likely due to a more intensive use of lipid-lowering drugs. Several metabolic parameters were higher (diabetes as much as 3.5-fold) in the group of severely TCDD-intoxicated subjects than in a general population of comparable age. This suggests that TCDD plays a role in the development of metabolic impairment and vascular changes. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2019
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