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Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals
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SYSNO ASEP 0490250 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals Author(s) Villa, I. (IT)
Villa, Ch. (IT)
Monguzzi, A. (IT)
Babin, Vladimir (FZU-D) RID, ORCID
Tervoort, E. (CH)
Nikl, Martin (FZU-D) RID, ORCID, SAI
Niederberger, M. (CH)
Torrente, Y. (IT)
Vedda, A. (IT)
Lauria, A. (CH)Number of authors 10 Source Title Nanoscale. - : Royal Society of Chemistry - ISSN 2040-3364
Roč. 10, č. 17 (2018), s. 7933-7940Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords cellular imaging ; luminescence Subject RIV BM - Solid Matter Physics ; Magnetism OECD category Condensed matter physics (including formerly solid state physics, supercond.) Institutional support FZU-D - RVO:68378271 UT WOS 000432261400007 EID SCOPUS 85046643061 DOI 10.1039/c8nr00724a Annotation Luminescent nanoparticles are researched for their potential impact in medical science, but no materials approved for parenteral use have been available so far. To overcome this issue, we demonstrate that Eu3+-doped hafnium dioxide nanocrystals can be used as non-toxic, highly stable probes for cellular optical imaging and as radiosensitive materials for clinical treatment. Furthermore, viability and biocompatibility tests on artificially stressed cell cultures reveal their ability to buffer reactive oxygen species, proposing an anti-cytotoxic feature interesting for biomedical applications. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2019
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