0485171 - ÚŽFG 2018 CZ eng K - Conference Paper (Czech conference)
Šmatlíková, Petra - Askeland, G. - Vaškovičová, Michaela - Klíma, Jiří - Motlík, Jan - Eide, L. - Ellederová, Zdeňka
Oxidative stress in primary porcine fibroblasts expressing mutated huntingtin.
The 4th Animal Models of Neurodegenerative Diseases. Liběchov: ÚŽFG AV ČR, v. v. i., 2017, s. 28-29.
[Animal Models of Neurodegenerative Diseases /4./. Liblice (CZ), 22.10.2017-24.10.2017]
R&D Projects: GA MŠMT(CZ) LO1609
Institutional support: RVO:67985904
Keywords : huntingtin
OECD category: Cell biology

Molecular events, such as protein aggregation, mitochondrial dysfunction, and transcriptional dysregulation have been linked to Huntington’s disease (HD) pathogenesis. Oxidative stress has been considered as one of the key players in disease progression. Though, it is still not clear whether oxidative stress causes HD, or if it is a consequence of other primary events.

Permanent Link: http://hdl.handle.net/11104/0280248