Autocrine effects of transgenic resistin on brown adipose tissue glucose and lipid metabolism

Trnovská, J.; Pravenec, Michal; Šilhavý, Jan; Strnad, Hynek; Eigner, Sebastian; Eigner-Henke, Kateřina; Škop, V.; Malinská, Hana; Kazdová, L.; Drahota, Zdeněk

doi:https://dx.doi.org/10.1016/j.atherosclerosis.2017.06.235

Number of the records: 1

Autocrine effects of transgenic resistin on brown adipose tissue glucose and lipid metabolism

1.

SYSNO ASEP	0484400
Document Type	A - Abstract
R&D Document Type	The record was not marked in the RIV
R&D Document Type	Není vybrán druh dokumentu
Title	Autocrine effects of transgenic resistin on brown adipose tissue glucose and lipid metabolism
Author(s)	Trnovská, J. (CZ) Pravenec, Michal (FGU-C)_{RID, ORCID} Šilhavý, Jan (FGU-C)_{RID, ORCID} Strnad, Hynek (UMG-J)_RID Eigner, Sebastian (UJF-V)_RID Eigner-Henke, Kateřina (FGU-C) Škop, V. (CZ) Malinská, Hana (BFU-R) Kazdová, L. (CZ) Drahota, Zdeněk (FGU-C)_{RID, ORCID}
Number of authors	10
Source Title	Atherosclerosis. - : Elsevier - ISSN 0021-9150 Roč. 263, č. 8 (2017), s. 71-71
Number of pages	1 s.
Publication form	Print - P
Action	85th Congress of the European-Atherosclerosis-Society (EAS)
Event date	23.04.2017 - 26.04.2017
VEvent location	Prague
Country	CZ - Czech Republic
Event type	EUR
Language	eng - English
Country	IE - Ireland
Keywords	Brown Adipose Tissue (BAT) ; Spontaneously Hypertensive Rat (SHR)
Subject RIV	FR - Pharmacology ; Medidal Chemistry
Subject RIV - cooperation	Institute of Physiology - Biochemistry Institute of Biophysics - Biophysics Institute of Molecular Genetics - Genetics ; Molecular Biology
R&D Projects	GA13-04420S GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823 ; BFU-R - RVO:68081707 ; UJF-V - RVO:61389005 ; UMG-J - RVO:68378050
UT WOS	000407634000202
DOI	10.1016/j.atherosclerosis.2017.06.235
Annotation	In SHR-Retn strain we observed lower relative weight of interscapular BAT (-22%; P<0.05). Expression of the mouse transgenic resistin was associated with a significantly reduced oxidation of both palmitate (-34%, P<0.007) and glucose (-40%, P<0.001) in isolated BAT. SHR-Retn transgenic rats versus SHR controls exhibited a substantially reduced incorporation of palmitate (-23%, P<0.01) but not glucose into BAT lipids. In addition, in vivo microPET imaging revealed significantly reduced 18FFDG uptake in BAT induced by exposure to cold in SHR-Retn versus control SHR (-31%, P<0.05).
Workplace	Nuclear Physics Institute
Contact	Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228
Year of Publishing	2018

Number of the records: 1