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Adaptive phylogeography of the bank vole (Clethrionomys glareolus): The role of functional divergence between populations in shaping current species distributions
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SYSNO ASEP 0484175 Document Type C - Proceedings Paper (int. conf.) R&D Document Type The record was not marked in the RIV Title Adaptive phylogeography of the bank vole (Clethrionomys glareolus): The role of functional divergence between populations in shaping current species distributions Author(s) Strážnická, Michaela (UZFG-Y) ORCID
Marková, Silvia (UZFG-Y) RID, ORCID
Searle, J. B. (US)
Kotlík, Petr (UZFG-Y) RID, ORCIDSource Title 12th International Mammalogical Congress. - Perth : IMC, 2017 - ISBN N Pages s. 223-224 Number of pages 2 s. Publication form Print - P Action International Mammalogical Congress /12./ Event date 09.07.2017 - 14.07.2017 VEvent location Perth Country AU - Australia Event type WRD Language eng - English Country AU - Australia Keywords bank vole ; adaptive phylogeography Subject RIV EA - Cell Biology OECD category Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology R&D Projects GA16-03248S GA ČR - Czech Science Foundation (CSF) LH15255 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF15_003/0000460 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UZFG-Y - RVO:67985904 Annotation The bank vole (Clethrionomys glareolus) represents an important model species in studies of adaptive phylogeography aimed at elucidating the role of selection in postglacial recolonisation. Functional variation in haemoglobin (Hb) distinguishing two bank vole populations that successively colonized Great Britain from different glacial refugia presumably helped facilitate the population
replacement. The two Hb variants are distinguished by a single amino acid substitution of serine by cysteine in the beta globin chain. The presence of extra cysteine in haemoglobin carried by the second colonising population demonstrably increases the antioxidant capacity of the red blood cells and it thus may have had a role in determining the adaptive advantage over the first colonists. Here, we found that both Hb variants are widely dispersed in continental Europe, showing a clear geographical pattern with each variant exhibiting association with a different phylogeographic lineage, as defined by mtDNA. This supports the functional differentiation of Hb between different refugial populations of the bank vole. The results from spatial analysis show that environmental conditions have a significant predictive value on Hb allele frequencies, which supports the hypothesis of the Hb divergence (and hence selection) being important in determining which glacial refugia were ultimately successful in populating the current bank vole distribution.Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2018
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