Development of 5 ' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals

0471925 - ÚMG 2017 RIV GB eng J - Journal Article
Trejbalová, Kateřina - Kovářová, Denisa - Blažková, Jana - Machala, L. - Jilich, D. - Weber, J. - Kučerová, Dana - Vencálek, O. - Hirsch, Ivan - Hejnar, Jiří
Development of 5 ' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals.
Clinical Epigenetics. Roč. 8, zima (2016), č. článku 19. ISSN 1868-7075. E-ISSN 1868-7083
R&D Projects: GA ČR GAP304/12/1736
Institutional support: RVO:68378050
Keywords : HIV-1 * latent reservoir * DNA methylation * chromatin conformation * latent HIV-1 provirus reactivation * HIV-1-infected individuals
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.987, year: 2016

Background: Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretroviral therapy (ART). We previously demonstrated that DNA methylation of HIV-1 long terminal repeat (5' LTR) restricts HIV-1 reactivation and, together with chromatin conformation, represents an important mechanism of HIV-1 latency maintenance. Here, we explored the new issue of temporal development of DNA methylation in latent HIV-1 5' LTR.
Permanent Link: http://hdl.handle.net/11104/0269289