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Microglial Janus kinase/signal transduction and activator of transcription 3 pathway activity directly impacts astrocyte and spinal neuron characteristics
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SYSNO ASEP 0458427 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Microglial Janus kinase/signal transduction and activator of transcription 3 pathway activity directly impacts astrocyte and spinal neuron characteristics Author(s) Molet, J. (FR)
Mauborgne, A. (FR)
Diallo, Michael (FGU-C)
Armand, V. (FR)
Geny, D. (FR)
Villanueva, L. (FR)
Boucher, Y. (FR)
Pohl, M. (FR)Source Title Journal of Neurochemistry. - : Wiley - ISSN 0022-3042
Roč. 136, č. 1 (2016), s. 133-147Number of pages 15 s. Language eng - English Country US - United States Keywords astrocytes ; cell plasticity ; JAK/STAT3 pathway ; microglia conditioned media ; spinal cord neurons Subject RIV FH - Neurology R&D Projects EE2.3.30.0025 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000367192700011 EID SCOPUS 84951191413 DOI 10.1111/jnc.13375 Annotation We show that the activity of JAK/STAT3 pathway in microglial cells confers them a specific signaling modality toward neighboring cells, promoting astrocyte proliferation and changes in neuronal morphology. These in vitro data suggest that the early JAK/STAT3 activation in spinal cord microglia, associated with peripheral nerve injury, participates in functional alteration of various cell populations and in spinal tissue remodeling. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2017
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